Elitacos™-PRO

Elitacos™ PRO壳寡糖与健康

经研究证明，其具有抗炎、抗氧化、改善糖脂代谢、抗肿瘤等多重生物学特性，并具有免疫调节能力。

Elitacos™ PRO的核心优势与作用机制

增强免疫
壳寡糖（120 mg/kg）可显著增强小鼠特异性体液免疫与细胞免疫，提升免疫球蛋白水平和ConA诱导的T淋巴细胞转化率。
· 增强细胞免疫与体液免疫¹
· 提升血清IgG水平，强化体液免疫应答² 
· 实现免疫平衡与抗炎双重作用³

改善糖代谢
高血糖人群每日摄入1.5g的壳寡糖，三个月后体脂率和腰围显著降低，血糖、糖化血红蛋白显著降低，炎症因子水平降低7。
· 显著提升体内GLP-1的水平⁴
· 显著提升体内胰岛素水平，改善胰岛素抵抗⁵
· 降低空腹血糖水平，改善血糖代谢能力⁶

促进营养吸收、改善体质
· 可以促进蛋白质的吸收
· 改善营养状况——针对虚弱、恶液质人群和肿瘤患者
· 恶液质国际共识定义⁸ —— 明确体重下降是核心诊断与预后指标
· Elitacos™ PRO壳寡糖通过改善营养吸收⁹和抑制系统性炎症¹⁰（已知的导致肌肉分解和体重丢失的关键驱动因素），直接针对了共识中定义的恶液质病理生理核心，为维持体重提供了多靶点干预策略。

抑制癌症肿瘤细胞
全球肿瘤患病呈发病率、死亡率持续攀升态势，发病谱兼具地域差异，肺癌、乳腺癌等为高发癌种，且老龄化、生活方式改变等因素进一步推动其流行。

Elitacos™ PRO针对癌症肿瘤人群，可以起到如下的作用：

· 抑制肿瘤细胞增殖和转移
· 在体内抑制肿瘤血管生成并增强抗氧化能力
· 诱导肿瘤细胞凋亡

已证实的抗肿瘤谱系
肝癌， 前列腺癌，乳腺癌，结肠癌，宫颈癌，骨肉瘤，胃癌，胰腺癌，肺癌

Elitacos™ PRO的产品特点

· 来源纯净

· 来自无污染海域

· 工艺优化

· 产品在气味、色泽、流散性上表现更佳，口感温和，安全可靠

· 应用产品

· 饮料、固体饮料、乳制品及保健品剂型、肉制品、烘焙食品等

· 技术依托

· 采用中国科学院过程工程研究所酶法定向降解技术，活性更高, 靶向应用效果好

参考文献

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2 Shun-Hsien Chang, Guan-James Wu, Chien-Hui Wu, Chung-Hsiung Huang, Guo-Jane Tsai, Oral administration with chitosan hydrolytic products modulates mitogen-induced and antigen-specific immune responses in BALB/c mice, International Journal of Biological Macromolecules, Volume 131, 2019,
Pages 158-166, ISSN 0141-8130
3 Li Y, Xu Q, Wei P, Cheng L, Peng Q, Li S, Yin H, Du Y. Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling. Int J Mol Med. 2014 Feb;33(2):392-400
4 Liu SH, Huang YW, Wu CT, Chiu CY, Chiang MT. Low molecular weight chitosan accelerates glucagon-like peptide-1 secretion in human intestinal endocrine cells via a p38-dependent pathway. J Agric Food Chem. 2013 May 22;61(20):4855-61.
5 Junping Zheng，Xubing Yuan，Gong Cheng，Siming Jiao，Cui Feng，Xiaoming Zhao，Heng Yin，Yuguang Du，Hongtao Liu. Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice. Carbohydrate Polymers. 2018, 190：77-86
6 Bai, Y.; Zheng, J.; Yuan, X.; Jiao, S.; Feng, C.; Du, Y.; Liu, H.; Zheng, L. Chitosan Oligosaccharides Improve Glucolipid Metabolism Disorder in Liver by Suppression of Obesity-Related Inflammation and Restoration of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ). Mar. Drugs 2018, 16, 455.
7 A Randomized Trial to Assess the Efficacy and Safety of GO2KA1(Chitosan Oligosaccharide)on Blood Glucose Control， NCT01496820
8 Fearon, K., Strasser, F., Anker, S. D., et al. (2011). Definition and classification of cancer cachexia: an international consensus. The Lancet Oncology, 12(5), 489-495.
9 Swiatkiewicz S, Swiatkiewicz M, Arczewska-Wlosek A, Jozefiak D. Chitosan and its oligosaccharide derivatives (chito-oligosaccharides) as feed supplements in poultry and swine nutrition. J Anim Physiol Anim Nutr (Berl). 2015 Feb;99(1):1-12. doi: 10.1111/jpn.12222. Epub 2014 Jul 12. PMID: 25041091.
10  T, Wongkrasant P, Chanchai S, Pichyangkura R, Chatsudthipong V, Muanprasat C. Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-κB and mTOR signaling. Carbohydr Polym. 2016 Jul 10;145:30-6. doi: 10.1016/j.carbpol.2016.02.077. Epub 2016 Mar 3. PMID: 27106148.
11 Jing, B.; Cheng, G.; Li, J.; Wang, Z.A.; Du, Y. Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem. Mar. Drugs 2019, 17, 415.
12 Haige Wu, Ziang Yao, Xuefang Bai, Yuguang Du, Xiaojun Ma, Chitooligosaccharides inhibit nitric oxide mediated migration of endothelial cells in vitro and tumor angiogenesis in vivo, Carbohydrate Polymers,
Volume 82, Issue 3, 2010, Pages 927-932, ISSN 0144-8617,
13 Liu et al., Afr J Tradit Complement Altern Med., (2017) 14 (4): 272-277 https://doi.org/10.21010/ajtcam.v14i4.30 INHIBITORY EFFECT OF CHITOSAN OLIGOSACCHARIDE ON HUMAN HEPATOMA CELLS IN VITRO
14 Jae Kweon Park et al., Int. J. Mol. Sci. 2011, 12, 266-277; Effects of the Molecular Weight and the Degree of Deacetylation of Chitosan Oligosaccharides on Antitumor Activity 
15 Nam et al., J. Microbiol. Biotechnol. (2009), 19(6), 629–633；Suppression of Metastasis of Human Breast Cancer Cells by Chitosan Oligosaccharides
16 Fu-Shi Han et al., World J Gastroenterol 2016 June 14; 22(22): 5193-5200；Chitooligosaccharides promote radiosensitivity in colon cancer line SW480
17 Mengyao Zhao et al., Carbohydrate Polymers Volume 224, 15 November 2019, 115171； Chitooligosaccharides display anti-tumor effects against human cervical cancer cells via the apoptotic and autophagic pathways
18 Jin Sim et al., Medical Oncology (2023) 40:294；Chitosan oligosaccharide suppresses osteosarcoma malignancy by inhibiting CEMIP via the PI3K/AKT/mTOR pathway
19 Zhiwen Jiang et al., European Journal of Pharmacology Volume 891, 15 January 2021, 173673； Effect of chitosan oligosaccharide-conjugated selenium on improving immune function and blocking gastric cancer growth；
20 Han Liu et al., Discover Oncology (2025) 16:298； Chitooligosaccharide impairs the proliferation, invasion and migration of pancreatic cancer cells
21 Yun-qiu Miao et al., Acta Pharmacologica Sinica (2021) 42:1714–1722; Chitosan oligosaccharide modified liposomes enhance lung cancer delivery of paclitaxel